
The game's title and plot are inspired by the Biblical story of the Binding of Isaac.
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The Binding of Isaac is an indie roguelike video game designed by Edmund McMillen and Florian Himsl, initially released in 2011 for Microsoft Windows the game was later ported for OS X, and Linux operating systems. Forever was eventually released in late 2020 for various platforms. McMillen later confirmed this in a blog post. In a 2017 interview with Eurogamer, Refenes revealed that McMillen was no longer a part of Team Meat and would not play a role in developing the game's sequel, Super Meat Boy Forever.

McMillen and Refenes responded to the success of Super Meat Boy and the impossibility of a sequel in a brief statement that read, "We feel like we did it.the 1st time." McMillen and Refenes' development of Super Meat Boy was featured in the film Indie Game: The Movie. Due to Sony's initial lack of interest in the game, Team Meat entered into contractual obligations that prohibit the game from being released for the Sony PlayStation 3. A retail version of the game was released on April 5, 2011. According to Kotaku, problems arose due to the file size limitations of the Wii's WiiWare Channel. A release was planned for the Nintendo Wii, but was canceled. Their first game, Super Meat Boy, was released on October 20, 2010, on the Xbox 360 via Xbox Live Arcade, and on Valve's digital distribution system Steam on November 30, 2010. McMillen and programmer Tommy Refenes established Team Meat, an independent game production company, with the intent that they would never utilize a third-party publisher. His game Aether was a 2009 IndieCade finalist and received an honorable mention. Braid went on to win the Innovation Award at the 2006 Independent Games Festival prior to its release, and several awards in 2008, including GameSpot's Best Platformer, and Best Original Downloadable Console Game, and the 12th Annual Academy of Interactive Arts & Sciences Awards Casual Game of the Year. McMillen was the original character artist and animator on Braid, before those assets were replaced by the work of David Hellman. His game Coil was nominated for the Innovation Award at the 2009 Independent Games Festival. Gish won Game Tunnel's 2004 Adventure Game of the Year, as well as Indie Game of the Year. McMillen is also known for the games Gish, Aether, The Binding of Isaac and Coil. His most well-known games are the Flash-based game Meat Boy, and its sequel Super Meat Boy, which has been released for PC, Xbox 360 and PlayStation 4.
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While he has largely abandoned this field in favor of video games, he has released a series of comics featuring Meat Boy, the title character in the video game Super Meat Boy, as a promotional tie-in for the game.

McMillen's initial graphic work was in independent comics. He was confronted by this extreme faith, which caused him religious guilt and mental problems causing him to grow a desire to fight back, resulting in his acting out against them.
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In an interview with Indie Game: The Movie he explains that his family was consistently riddled with alcohol and drug addiction, as well as being “born again” Christians. His childhood represents his own game creations, more specifically The Binding of Isaac: Rebirth. Many of these drawings can be seen by unlocking The Box in one of his games, The Basement Collection.

Later in his life, McMillen received a box from his grandmother that contained all of his drawings as a child. McMillen spent most of his childhood with his grandmother, whom he considers to be the greatest source of support in his creative endeavors. He is fond of drawing, his favorite subject being monsters. Microgames from WarioWare: D.I.Y.McMillen has been a lifelong resident of Santa Cruz, California.
